Clostridium difficile

Recent News

Apr 24, 2017
Clostridium difficile in petri dish

European studies note high impact, spread of C difficile

Within 2 months of admission, 29% of C diff patients died, compared with 14% of the control group.

Mar 29, 2017
heartburn

Heartburn drugs tied to higher risk of recurrent C diff

A 16-study meta-analysis finds about a 50% higher risk tied to anti-reflux drugs.

Mar 28, 2017

News Scan for Mar 28, 2017

New NIH cuts
Yellow fever from Suriname
Measles in Europe
C diff in surgical patients
New chikungunya cases
Food safety in cookbooks
Mar 07, 2017

News Scan for Mar 07, 2017

Puerto Rico Zika rate
Yellow fever in Brazil
Cholera outbreak in Yemen
Review of C diff antibiotics
Susceptible bacteria in UTIs
Mar 06, 2017

Stewardship / Resistance Scan for Mar 06, 2017

Antibiotic use for ear infections
Community-onset C diff
Feb 16, 2017

News Scan for Feb 16, 2017

H5N8 in Israel, Europe
Vaccine safety
Imported-food outbreaks
C diff cluster
Leptospirosis in NYC
Feb 06, 2017

Study: Vancomycin should be go-to drug for severe C diff

The drug may cut all-cause mortality in patients with severe C difficile infection.

Jan 26, 2017
Clostridium difficile

New treatment for recurrent C diff shows promise

Two phase 3 trials showed that a human mononoclonal antibody cut recurrence about 40%.

Jan 26, 2017

Stewardship / Resistance Scan for Jan 26, 2017

VA antibiotic stewardship
Antimicrobial use in food animals
MDR Staph capitis in NICUs
Jan 25, 2017
Pills on hospital tray

Study finds reduced antibiotic use could cut C diff

Though a UK C diff spike was thought to be caused by dirty hospital rooms, that theory proved unlikely.

Resources & Literature

Recent Literature

Anderson DJ, Chen LF, Weber DJ, et al. Enhanced terminal room disinfection and acquisition and infection caused by multidrug-resistant organisms and Clostridium difficile (the Benefits of Enhanced Terminal Room Disinfection study): a cluster-randomised, multicentre, crossover study. Lancet 2017 (published online Jan 16)

Chen Y, Glass K, Liu B, et al. Burden of Clostridium difficile infection: associated hospitalization in a cohort of middle-aged and older adults. Am J Infect Control 2017 (published online Jan 14)

Dingle KE, Didelot X, Quan TP, et al. Effects of control interventions on Clostridium difficile infection in England: an observational study. Lancet Infect Dis 2017 (published online Jan 24)

Gross AE, Johannes RS, Gupta V, et al. The effect of a piperacillin/tazobactam shortage on antimicrobial prescribing and Clostridium difficile risk in 88 U.S. medical centers. Clin Infect Dis 2017 (published online Apr 24)

Hung YP, Huang IH, Lin HJ, et al. Predominance of Clostridium difficile ribotypes 017 and 078 among toxigenic clinical isolates in Southern Taiwan. PLoS One 2016 Nov 18;11(11):e0166159

Nanwa N, Sander B, Krahn M, et al. A population-based matched cohort study examining the mortality and costs of patients with community-onset Clostridium difficile infection identified using emergency department visits and hospital admissions. PLoS One 2017 Mar 3;12(3):e0172410

Nelson RL, Suda KJ, Evans CT. Antibiotic treatment for Clostridium difficile-associated diarrhoea in adults. Cochrane Libr 2017 (published online Mar 3)

Staley C, Kelly CR, Brandt LJ, et al. Complete microbiota engraftment is not essential for recovery from recurrent Clostridium difficile infection following fecal microbiota transplantation. mBio 2016 Dec 20;7(6):e01965-16

Suljagic V, Milijkovic I, Starcevic S, et al. Risk factors for Clostridium difficile infection in surgical patients hospitalized in tertiary hospital in Belgrade, Serbia: a case-control study. Antimicrob Resist Infect Control 2017 (published online Mar 27)

Tariq R, Singh S, Gupta A, et al. Association of gastric acid suppression with recurrent Clostridium difficile infection: a systematic review and meta-analysis. JAMA Intern Med 2017 (published online Mar 27)

Widmer AF, Frei R, Erb S, et al. Transmissibility of Clostridium difficile without contact isolation: results from a prospective observational study with 451 patients. Clin Infect Dis 3016 (published online Nov 15)

Wilcox MH, Gerding DN, Poxton IR, et al. Bezlotoxumab for prevention of recurrent Clostridium difficile infection. N Engl J Med 2017 Jan 26;376(4):305-17

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