Malaria

Recent News

Apr 25, 2017
Anopheles mosquito emerging from water

Returning travelers cause sizable malaria burden in US

New study estimates about 2,100 travelers return with the disease each year and almost 1,500 need hospitalization.

Apr 25, 2017

News Scan for Apr 25, 2017

H7N9 cases in China
New USDA secretary
Malaria immune response
Apr 05, 2017
Rapid diagnostic testing

Rapid malaria tests tied to increased antibiotic use

Meta-analysis shows a 21% higher antibiotic prescribing rate in patients who tested negative for malaria.

Mar 29, 2017
Malaria sporozoites

Studies show single-dose potential for new malaria drug

Two studies suggest DSM265 is a medium-potency, slowly eliminated, well-tolerated antimalarial.

Mar 01, 2017

News Scan for Mar 01, 2017

Flu antivirals in pregnancy
Ebola deaths
Aedes aegypti and Zika
Feb 23, 2017

Stewardship / Resistance Scan for Feb 23, 2017

Resistant malaria in Africa
Antibacterial skin lotion
Feb 17, 2017

News Scan for Feb 17, 2017

Zika birth defects
More yellow fever
Limiting dengue
Malaria in the Americas
H5N8 outbreaks
Feb 15, 2017

News Scan for Feb 15, 2017

H7N9 cases in China
Zika in body fluids
Yellow fever vaccine
Malaria vaccine trial
Feb 02, 2017
Kids with bed net

Malaria resistance: Cases in UK, mosquitoes in Africa

UK researchers report that a frontline drug combo failed in 4 patients.

Feb 01, 2017

Stewardship / Resistance Scan for Feb 01, 2017

Spread of MCR-1 gene
Resistant asymptomatic malaria
ESBL bacteria in travelers

Resources & Literature

Recent Literature

Brasil P, Zalis MG, de Pina-Costa A, et al. Plasmodium simium causing human malaria: a zoonosis without break potential in the Rio de Janeiro Brazilian Atlantic forest. bioRxiv 2017 Mar 29

Churcher TS, Sinden RE, Edwards NJ, et al. Probability of transmission of malaria from mosquito to human is regulated by mosquito parasite density in naive and vaccinated hosts. PLoS Pathog 2017 Jan 12;13(1):e1006108

Gething PW, Casey DC, Weiss DJ, et al. Mapping Plasmodium falciparum mortality in Africa between 1990 and 2015. N Engl J Med 2016 Dec 22;375(25):2435-45

Gutman J, Kovacs S, Dorsey G, et al. Safety, tolerability, and efficacy of repeated doses of dihydroartemisinin-piperaquine for prevention and treatment of malaria: a systematic review and meta-analysis. Lancet Infect Dis 2016 (published online Nov 16)

 

Hoglund RM, Workman L, Edstein MD, et al. Population pharmacokinetic properties of piperaquine in falciparum malaria: an individual participant data meta-analysis. PLoS Med 2017 Jan 10;14(1):e1002212

Imwong M, Suwannasin K, Kunasol C, et al. The spread of artemisinin-resistant Plasmodium falciparum in the Greater Mekong Subregion: a molecular epidemiology observational study. Lancet Infect Dis 2017 (published online Feb 1)

Khuu D, Eberhard ML, Bristow BN, et al. Malaria-related hospitalizations in the United States, 2000-2014. Am J Trop Med Hyg 2017 (published online Apr 24)

Killeen GF, Masalu JP, Chinula D, et al. Control of malaria vector mosquitoes by insecticide-treated combinations of window screens and eave baffles. Emerg Infect Dis 2017 (published online Mar 23)

Kolifarhood G, Raeisi A, Ranjbar M, et al. Prophylactic efficacy of primaquine for preventing Plasmodium falciparum and Plasmodium vivax parasitaemia in travelers: a meta-analysis and systematic review. Travel Med Infect Dis 2017 (published online Apr 24)

Kublin JG, Mikolajczak SA, Sack BK, et al. Complete attenuation of genetically engineered Plasmodium falciparum sporozoites in human subjects. Sci Transl Med 2017 Jan 4;9(371)

Lima JMT, Vittor A, Rifai S, et al. Does deforestation promote or inhibit malaria transmission in the Amazon? A systematic literature review and critical appraisal of current evidence. Philos Trans R Soc Lond B Biol Sci 2017 (published online Apr 24)

Lo E, Lam N, Hemming-Schroeder E, et al. Frequent spread of Plasmodium vivax malaria maintains high genetic diversity at the Myanmar-China border without distance and landscape barriers. J Infect Dis 2017 (published online Mar 3)

Lu F, Culleton R, Zhang M, et al. Emergence of indigenous artemisinin-resistant Plasmodium falciparum in Africa. (Letter) N Engl J Med 2017 (published online Feb 22)

Mawili-Mboumba DP, Ella RNN, Rosa NB, et al. Submicroscopic falciparum malaria in febrile individuals in urban and rural areas of Gabon. Am J Trop Med Hyg 2017 (published online Feb 20)

McCarthy JS, Lotharius J, Ruckle T, et al. Safety, tolerability, pharmacokinetics, and activity of the novel long-acting antimalarial DSM265: a two-part first-in-human phase 1a/1b randomised study. Lancet Infect Dis 2017 (published online Mar 28)

Nyunt MH, Shein T, Zaw NN, et al. Molecular evidence of drug resistance in asymptomatic malaria infections, Myanmar, 2015. Emerg Infect Dis 2017 (published online Jan 31)

Ochomo E, Chahilu M, Cook J, et al. Insecticide-treated nets and protection against insecticide-resistant malaria vectors in western Kenya. Emerg Infect Dis 2017 (published online Mar 27)

Paquet T, Le Manach C, Cabrera DG, et al. Antimalarial efficacy of MMV390048, an inhibitor of Plasmodium phosphatidylinositol 4-kinase. Sci Transl Med 2017 Apr 26;9(387):eaad9735

Phuc BQ, Rasmussen C, Duong TT, et al. Treatment failure of dihydroartemisinin/piperaquine for Plasmodium falciparum malaria, Vietnam. (Letter) Emerg Infect Dis 2017 (published online Mar 17)

Raouf S, Mpimbaza A, Kigozi R, et al. Resurgence of malaria following discontinuation of indoor residual spraying of insecticide in a previously high transmission intensity area of Uganda. Clin Infect Dis 2017 (published online Mar 24)

Rees E, Saavedra-Campos M, Usdin M, et al. Trend analysis of imported malaria in London: observational study 2000 to 2014. Travel Med Infect Dis 2017 (published online Apr 26)

Sissoko MS, Healy SA, Katile A, et al. Safety and efficacy of PfSPZ vaccine against Plasmodium falciparum via direct venous inoculation in healthy malaria-exposed adults in Mali: a randomised, double-blind phase 1 trial. Lancet Infect Dis 2017 (published online Feb 15)

Sulyok M, Ruckle T, Roth A, et al. DSM265 for Plasmodium falciparum chemoprophylaxis: a randomised, double blinded, phase 1 trial with controlled human malaria infection. Lancet Infect Dis 2017 (published online Mar 28)

Thomsen EK, Koimbu G, Pulford J, et al. Mosquito behavior change after distribution of bednets results in decreased protection against malaria exposure. J Infect Dis 2016 (published online Dec 22)

Tumwebaze P, Tukwasibwe S, Taylor A, et al. Changing antimalarial drug resistance patterns identified by surveillance at three sites in Uganda. J Infect Dis 2016 (published online Dec 29)

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